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Image Search Results
Journal: Antioxidants
Article Title: Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice
doi: 10.3390/antiox12030722
Figure Lengend Snippet: CY-09 restored the insulin signaling pathway in 3×Tg-AD mice. ( a – h ) Western blot analysis of insulin receptors (IR), p-IR-Tyr1150, insulin receptor substrate (IRS), p-IRS-Ser1101, AKT, p-AKT-Ser473, AS160 and p-AS160-Thr642 in NTg, NTg + CY-09, 3×Tg-AD, and 3×Tg-AD + CY-09 mice. (n = 6, mean ± SD, one-way ANOVA and Bonferroni post hoc test; * p < 0.05, ** p < 0.01 vs. NTg mice, & p < 0.05, && p < 0.01 vs. NTg + CY-09 mice, # p < 0.05 vs. 3×Tg-AD mice). ( i ) Distribution of IR and p-IR-Tyr1150 in the brains of the four groups of mice (scale bar: 100 μm; arrows indicate p-IR in 3×Tg-AD + CY-09 mice).
Article Snippet: Antibodies against IRS (Cat#3407),
Techniques: Western Blot